Basant Hamdy Elrefaey, Heba Ali Abd EL-Ghaffaar,Doaa Mohammed Mahmoud Allam, Mohamed Abd EL-Motaal Safa

Basant Hamdy Elrefaey, Heba Ali Abd EL-Ghaffaar,Doaa Mohammed Mahmoud Allam, Mohamed Abd EL-Motaal Safa – Acute aerobic Exercise Induced Irisin Release in Type 2 Diabetic patients: Randomized Clinical Trial. Fizjoterapia Polska 2019; 19(4); 58-63

Abstract
Background. Type 2 diabetic subjects have lower irisin level, irisin discovery has provides a modern track for energy homeostasis and opens a chance for development of curative components to manage metabolic disorders. Purpose: The Objective of this study was to explore acute irisin response to two different types of aerobic training modes in type 2 diabetics. Methods. Thirty-one type 2 diabetic patients aged between 45 and 60 years, were randomly assigned into two exercise groups: (EX1) group (n = 16) who received continuous aerobic exercise and (EX2) group (n = 15) who received interval aerobic exercise. The program in both groups was in the form of treadmill walking for 60 min. Blood collection of primary outcome (irisin) and assessment of oxygen saturation (SpO2) and heart rate (HR) were done at baseline and immediately after single aerobic bout. 6MWT was used to determine individual training intensity for each subject.
Results. After single aerobic exercise bout, there was significant improvement in irisin in both groups (p = 0.0001, 0.01 respectively), increase in HR (p = 0.0001 in both groups) & decrease in SPO2 in EX1 (p = 0.002) with non significant difference between groups in the mean values of HR & SpO2 post exercise (p < 0.05),however there was significant difference between groups in the mean values of irisin level favoring EX1 group (p = 0.03). Conclusion. Acute aerobic exercise is effective in improving irisin level in type 2 diabetes and the superiority in irisin improvement was to continuous exercise than interval exercise. Further studies are required to discover irisin response in type 2 diabetes with different types of exercise protocols rather than aerobics.

Key words:
acute, aerobic exercise, irisin, type 2 diabetes

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