Abstract
Introduction. The usage of innovative therapeutic methods in the field of dentistry is con-stantly being researched with a goal to find an effective and safe strategies for the treatment of periodontal and oral mucosal diseases. In recent years, ozone therapy has become a subject of increased interest due to its potential benefits in the field of dental therapy. Ozone, the triatomic gas of oxygen, has gained prominence as an alternative form of therapy that can affect pathological changes within the oral cavity given its antibacterial and antifungal properties.
Purpose of the study. The aim of this literature review is to evaluate the effectiveness of ozone therapy in dental treatment, with particular emphasis on the effect on periodontal and oral mucosal diseases, as well as tissue regeneration and reduction of pathogenic microorgan-isms within the oral cavity.
Materials and methods. A systematic review of international literature published between 2000 and 2023 was conducted. This analysis included electronic databases such as PubMed, Google Scholar and EBSCO with the intention to collect and examine research findings. The selection of scientific papers was made taking into account the diversity of topics, methodological rigor and adherence to the principles of research ethics. In order to identify publications that met the established selection criteria, a multi-stage evaluating process was used, subjecting the chosen papers to critical evaluation.
Conclusions. The usage of ozone therapy is a vast field of scientific research, subject to con-tinuous analysis, where the results are not always unanimous. In recent years, there has been noted a significant involvement of ozone (O3) in the field of periodontics and other dental disciplines. The effects of ozone and its therapeutic potential are a subject of detailed scientific research aimed at understanding the biological mechanisms and confirming the effectiveness of this form of therapy.

Keywords
ozone, ozone therapy, therapeutic applications, oxidants, dental disinfectants, oral medicine, physical therapy in dentistry, periodontal diseases, oral mucosal diseases