Tag: Antony Leo Aseer P

Association between pain type, physical activity and regional function in individuals with chronic low back pain

Siva Harini Y, Balamurugan B, Antony Leo Aseer P, Subbiah K, Angeline R

Siva Harini Y, Balamurugan B, Antony Leo Aseer P, Subbiah K, Angeline R – Association between pain type, physical activity and regional function in individuals with chronic low back pain –  Fizjoterapia Polska 2025; 25(4); 129-133

DOI: https://doi.org/10.56984/8ZGA431YTPJ

Abstract
Background. Chronic low back pain (CLBP) is often associated with disability and decreased quality of life. Understanding the distinction between nociceptive and neuropathic pain is important, as each may differently affect physical activity and function.
Aim. To examine the association between pain type, physical activity, and regional function in individuals with CLBP.
Methodology. A total of 70 participants aged 20–55 years with CLBP were recruited. Pain type was classified using the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS). Physical activity was assessed with the Global Physical Activity Questionnaire (GPAQ), and regional function was evaluated using the Oswestry Disability Index (ODI). An independent t-test was performed to analyze the data.
Results. The neuropathic pain group showed significantly higher pain intensity (p < 0.01), greater functional disability (p < 0.01), and lower levels of physical activity (p < 0.01) compared to the nociceptive group. A strong negative correlation was observed between physical activity and disability, emphasizing the role of active management in CLBP.
Conclusion. Individuals with neuropathic pain experience more severe disability and engage in less physical activity than those with nociceptive pain. Assessing the pain type is essential in determining appropriate rehabilitation strategies for managing CLBP.
Key words
chronic low back pain, neuropathic pain, nociceptive pain, physical activity, disability
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Deciphering the role of otolin-1 in predicting benign paroxysmal positional vertigo severity and recurrence: a comprehensive scoping review

Hepzibah Rubella D, Antony Leo Aseer P, Mr. Soundararajan K

Hepzibah Rubella D, Antony Leo Aseer P, Mr. Soundararajan K – Deciphering the role of otolin-1 in predicting benign paroxysmal positional vertigo severity and recurrence: a comprehensive scoping review –  Fizjoterapia Polska 2025; 25(3); 403-407

DOI: https://doi.org/10.56984/8ZG7D19TVZF

Abstract
Background. Benign paroxysmal positional vertigo (BPPV) is the most common vestibular disorder, characterized by extremely short episodes of vertigo. Recent studies have identified serum otolin-1 as a potential biomarker for BPPV, useful in predicting symptom severity and recurrence. This scoping review summarizes published evidence on the relationship between serum otolin-1 and BPPV, highlighting major trends, research gaps, and future directions.
Methods. A comprehensive literature search was conducted using PubMed, Scopus, Web of Science, and Google Scholar to identify relevant studies published from January 2020 to the present. Studies were included if they reported on the association between serum otolin-1 levels and BPPV in human subjects. Data were extracted using a structured form and synthesized through descriptive and thematic analysis.
Results. Five studies met the inclusion criteria, with a total sample size of 342 participants from various geographic regions. The results showed that serum otolin-1 levels were significantly higher in BPPV patients compared to controls. Kim et al. (2024) reported otolin-1 levels of 350.1±319.1 pg/mL in BPPV patients versus 183.6±134.1 pg/mL in other positional vertigo patients (p = 0.037). Similar trends were observed in Yadav et al. 2021, Aygun et al. 2024, Fan et al. 2022, and Wu Y et al. 2022. However, many of the included studies had limitations, such as small sample sizes and single-centre designs.
Conclusion. The consistent association between elevated serum otolin-1 levels and BPPV suggests a potential role as a biomarker for predicting severity and recurrence. Nevertheless, significant limitations remain, including the need for larger, multicentre studies and longitudinal follow-up to confirm these findings. Further research should address these gaps to make serum otolin-1 a clinically useful tool in BPPV management.
Key words
bppv, positional vertigo, otolin 1, biomarkers, outcome measure, diagnostic tools
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