Abstract
Aim. Ramadan fasting involves intermittent energy restriction, altered sleep patterns, and circadian disruption. However, direct assessment of corticospinal excitability remains limited. This study examined changes in motor-evoked potentials (MEPs) during Ramadan fasting using single-pulse transcranial magnetic stimulation (TMS), alongside cognitive and metabolic measures.
Materials and methods. Twenty-eight healthy adults (mean age 20.2 ± 1.7 years) observing Ramadan fasting completed assessments at two time points: pre-Ramadan (T1) and mid-Ramadan (T2). Corticospinal excitability was assessed using MEP amplitude and latency elicited by single-pulse TMS over the primary motor cortex. Concurrent measures included a visual working memory (VWM) test, the Stroop test, capillary glucose level, and self-reported sleep duration.
Results. Significant reductions were observed in glucose levels and sleep duration during fasting, whereas VWM performance improved; however, this improvement may reflect practice effects and the absence of a control group rather than fasting-related enhancement. No significant changes were detected in MEP amplitude, MEP latency, or Stroop test performance. Changes in MEP parameters were not significantly correlated with changes in metabolic or cognitive measures.
Conclusion. Under the single-pulse TMS protocol used, corticospinal excitability showed no detectable change during mid-Ramadan fasting. These preliminary findings should be interpreted cautiously given the limited sample size, absence of a control group, and the protocol’s constrained sensitivity.
Key words
transcranial magnetic stimulation, Ramadan, intermittent fasting, cognitive function, motor-evoked potentials, cortical excitability