Maisarah Mohd Saleh, Roxana Dev Omar Dev, Adam Linoby, Iqbal Norhamazi, Rozella Ab Razak, Azrisan Ahsan, Norhasmah Sulaiman
Ashwinkumar Chandrashekarapuram Swaminathan et al. – The effect of nitrate supplementation on exercise performance – an umbrella review of meta-analyses – Fizjoterapia Polska 2025; 25(1); 356-363
DOI: https://doi.org/10.56984/8ZG007D9ZWE
Abstract
There is often a lack of agreement in the outcomes of meta-analyses exploring the performance-boosting effects of nitrate supplements. The present study conducts a detailed assessment of existing meta-analyses on the impact of dietary nitrate on exercise efficiency, applying a comprehensive review strategy. Research articles were sourced from electronic databases, including EBSCOhost, PubMed, Scopus, and Web of Science. The methodological rigor of these meta-analyses was evaluated using established tools—AMSTAR 2—and was found to be moderate on average. The findings indicate that nitrate supplementation leads to a small but significant enhancement in exercise performance by 0.10% compared to a placebo. However, the benefit is specific to aerobic endurance, which saw an improvement of 0.11%, while no significant effects were observed for muscle endurance, strength, or anaerobic capacity. Notably, muscle endurance performance tends to improve with nitrate supplementation by 0.31% (P = 0.07). In summary, the current work indicates that nitrate supplementation can improve exercise performance, with the magnitude of the effect being greater in aerobic endurance compared to anaerobic performance.
Key words
nitrate, supplementation, exercise performance, umbrella review, meta-analysis