Ultrasonic wave-induced damage to human red blood cells

Iwona Pyszczek, Jan Talar, Jolanta Kujawa, Leu Zavodnik, Ewa Kilańczyk

Iwona Pyszczek, Jan Talar, Jolanta Kujawa, Leu Zavodnik, Ewa Kilańczyk – Ultrasonic wave-induced damage to human red blood cells. Fizjoterapia Polska 2002; 2(2); 134-139

Abstract
Background. The aim of this study was to evaluate the response of human red blood cells to physiotherapeutic ultrasound (1 MHz). Material and methods. The susceptibility of erythrocytes to ultrasonic wave-induced damage was indicated by cell hemolysis, changes in the electrochemical properties of cell membranes, and membrane-bound acetylcholinesterase activity. Results. Exposure of erythrocytes to ultrasound resulted in dose-dependent hemolysis, significant activation of membrane acetylcholineterase due to an increase in substrate affinity, slight membrane depolarization due to nonselective pore formation, and activation of membrane lipid peroxidation. Conclusions. These results show the significant biomodulation effect of the ultrasonic waves used in medical practice on human erythrocytes at the membrane and cellular level.

Key words:
physiotherapy, Hemolysis, acetylcholinestrerase

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