Abstract

Purpose. To determine the effect of Transdermal Delivery of Insulin by Low Intensity Ultrasound in healing of chronic lower limb venous ulcer. Methods. Sixty males and females participants who had chronic lower limb venous ulcer participated in this study. Their ages ranged from 40 to 60 years, distributed randomly into: group (A), 30 participants who received Transdermal Delivery of Insulin by Low Intensity Ultrasound in addition to regular medical care, and group (B), 30 participants who received topical insulin in addition to regular medical care. Both groups were evaluated pre-treatment, after 4 and 8 weeks from the beginning of the treatment by using (image j) software for measuring the ulcer surface area and normal saline for measuring the ulcer volume. Results. By comparison between both groups post treatment there were statistically significant decreases (P < 0.05) in wound surface area and wound volume in favor of group (A). Conclusion. transdermal delivery of insulin is a safe, non-invasive and beneficial modality in the treatment of lower limb venous ulcer and can be added to the treatment protocols for these debilitating conditions.

Key words:

transdermal delivery of insulin, topical insulin, low intensity ultrasound, chronic venous ulcer