Tag: interleukin-6

Effects of soleus muscle push-ups on oxidative stress, inflammatory markers and adipocytokines. A scoping review

Amenah Hisham, Hayder A. Hasan, Kalyana Chakravarthy Bairapareddy

Amenah Hisham, Hayder A. Hasan, Kalyana Chakravarthy Bairapareddy – Effects of soleus muscle push-ups on oxidative stress, inflammatory markers and adipocytokines. A scoping review –  Fizjoterapia Polska 2025; 25(2); 120-127

DOI: https://doi.org/10.56984/8ZG00E15H6O

Abstract
Sedentary lifestyle is highly prevalent nowadays due to prolonged sitting hours at work, the use of vehicles for transportation instead of walking, and limited physical activity. Such a lifestyle can increase the risk for chronic disorders such as obesity, type 2 diabetes mellitus (T2DM), and hypertension. Activity performed in a sitting position may be a feasible alternative; one such exercise is soleus push-ups (SPU), a low-impact sitting exercise that might modulate various biomarkers such as inflammatory markers and oxidative stress. Hence, our review aims to examine the impact of SPUs on certain markers, including oxidative stress markers, inflammatory markers, and adipocytokines, as this is the first research of its kind to target additional blood markers in relation to SPUs. The findings will be useful in shaping a national cultural health intervention program in an easy, affordable, and sustainable modern way to prevent the escalating prevalence of metabolic derangements.
Keywords
adipocytokines, inflammatory markers, oxidative stress markers, leptin, adiponectin, resistin, interleukin 6, interleukin 10, TNF-α, obesity, type 2 diabetes
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Impact of resistance training on salivary interleukin-6 and c-reactive protein – A scoping review

Kilani Kusuma, Hari Hara Subramanyan P.V, Mahesh Kumar P.G, Kamalakannan.M, Shenbaga Sundaram Subramanian, Abdel Razzaq Al Hadidi, Riziq Allah Mustafa Gaowgzeh, Ahmed Fekry Salman

 

Kilani Kusuma et al. – Impact of resistance training on salivary interleukin-6 and c-reactive protein – A scoping review –  Fizjoterapia Polska 2024; 24(4); 20-24

DOI: https://doi.org/10.56984/8ZG01A8A9K8

Abstract
This review examines the impact of resistance training on salivary interleukin-6 (IL-6) and C-reactive protein (CRP). These biomarkers are essential indicators of inflammation and immune response. The study employed a systematic literature review method following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. 20 articles published so far were included in the literature review, sourced from various databases: PubMed, Google Scholar, ERIC, EBSCO, Embase, Medline, Global Health, and Scopus. Keywords including MESH terms “resistance training,” “salivary IL-6,” “salivary CRP,” and “inflammation.” The inclusion criteria were fixed to studies that involved human participants, measured salivary IL-6 and CRP, and incorporated resistance-training protocols. Studies were excluded if they focused on other forms of exercise or used invasive measurement techniques and were not randomized control traits or quasi-experimental trials. The study population in these articles includes a diverse range of patients, such as the general population, adults, elderly adults, individuals with type 2 diabetes, COVID-19 patients with and without diabetes, patients with systemic inflammation and cardiovascular disease, overweight and obese individuals, and men with varying levels of physical fitness. By focusing on salivary measurements, this review emphasizes non-invasive methods for monitoring the physiological effects of resistance training. This review highlights the potential of resistance training to modulate inflammation as measured by salivary biomarkers. It underscores the importance of considering various factors when designing training programs and interpreting their physiological impacts. The variability in findings suggests that the relationship between resistance training and salivary IL-6 and CRP is complex. The reductions in these markers observed in some studies may be attributed to the anti-inflammatory effects of regular exercise. The final remarks from an intense review of the literature have shown resistance training has the potential to influence salivary IL-6 and CRP levels, reflecting changes in systemic inflammatory and immune responses. However, the impact varies based on training protocols and individual differences. Resistance training and biomarkers have practical applications in physiotherapy, such as developing tailored treatment programs, making progressive load adjustments, selecting appropriate exercise modalities, and providing patient feedback and monitoring. Additionally, more focused studies could investigate the underlying mechanisms behind observed outcomes, and new technologies such as advanced imaging and biomarkers could be incorporated to gain deeper insights. Research could also explore the impact of combining resistance training with other therapeutic modalities or investigate the role of individualized treatments in enhancing patient outcomes.
Keywords
resistance training, interleukin-6, C-reactive protein
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Effect of whole body vibration versus high intensity interval training on interleukin-6 in obese post-menopausal women

Fayka E Ali, Fahima M Okeel, Amir A Gabr, Amel M Yousef, Abdullah M. Al-Shenqiti, Mohamed Ahmed Elbedewy


Fayka E Ali, Fahima M Okeel, Amir A Gabr, Amel M Yousef, Abdullah M. Al-Shenqiti, Mohamed Ahmed Elbedewy – Effect of whole body vibration versus high intensity interval training on interleukin-6 in obese post-menopausal women. Fizjoterapia Polska 2022; 22(2); 144-149

Abstract
Background. Menopause and aging affect the health of obese women, provoking accumulation of visceral adipose tissue (VAT) and inflammation. Obesity leads to major health problems, which increase the risk of debilitating diseases that lead to death. Thus, loss of weight and VAT are primary goals of treatment through modifications of dietary habits and exercise. Purpose of the study. This study was conducted to determine which is more effective on interleukin- 6 (IL-6) levels for obese post-menopausal women, whole body vibration training (WBVT) or high intensity interval training (HIIT). Subjects and methods. 45 post-menopausal obese women diagnosed with higher level of IL-6, their body mass index (BMI) > 30 kg/m2 and waist/hip ratio (W/H ratio) > 0.8 participated at this study. Women were divided randomly into 3 equal groups in numbers; Group (A) followed low caloric diet (1200 Cal), Group (B) received WBVT and Group (C) received HIIT. Both groups (B & C) followed the same low caloric diet as group (A). Evaluation was done before and after 3 months of treatment, through measuring weight, BMI, waist as well as hip circumferences, W/H ratio and IL-6 levels. Results. The three groups revealed statistically significant improvements (P < 0.05) in all parameters after treatment compared to baseline. Also, there were statistically differences between the 3 groups after treatment, with the group (B) more favorable than groups (A & C). Conclusion. WBVT is more effective than HIIT on reducing inflammation via reducing IL-6 level in obese post-menopausal women.
Key words:
obesity, menopause, whole body vibration exercise, high intensity interval training, interleukin-6
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Effect of aerobic exercise on functional capacity and interleukin-6 level post allogeneic hematopoietic stem cell transplantation: A randomized controlled trial

Mohamed Rafat Borham, Azza Abdelaziz Abdelhady, Gamaleldin Mohamed Fathy, Emad Mohamed Ibrahim

Mohamed Rafat Borham, Azza Abdelaziz Abdelhady, Gamaleldin Mohamed Fathy, Emad Mohamed Ibrahim – Effect of aerobic exercise on functional capacity and interleukin-6 level post allogeneic hematopoietic stem cell transplantation: A randomized controlled trial. Fizjoterapia Polska 2022; 22(1); 100-107

Abstract
Background. Transplantation of hemopoietic stem cells has been extensively used as a curative modality to treat blood malignancies and cases of bone marrow failure. Objective. To examine the effect of aerobic exercises on functional capacity and interleukin-6 levels on patients post allogeneic hematopoietic stem cell transplantation (HSCT). Design. A quasi-experimental, randomized, single-blind design. Setting. Nasser Institute’s out-patient clinic for bone marrow transplant and Belqas central hospital. Methods. Forty women having chronic Graft versus Host Disease post hemopoietic stem cell allotransplant, with an age range of 20 to 30 years and body mass index between 18.5 and 24.9 kg/m2, were randomly designated into two equal groups (n = 20) (A and B). The study group (A) participated in a supervised aerobic exercise program of moderate intensity, with a score of 12-14 on the Borg scale for ‎perceived exertion, together with a specific medication routine, whereas the control group (B) was only given their medication routine. The exercise program consisted of 40 minutes on the stationary bicycle, with a warm-up and a cool-down period of 5 minutes each and 30 minutes as an active phase, 3 times per week for 3 months Both functional capacity, measured by a 6-minute walk test (6 MWT), and interleukin-6 blood level were assessed before starting the aerobic training and medical routine and after 3 months of the intervention. Results. The analysis showed a significant increase (P < .001) in the distance walked and assessed by 6 MWT in the group (A) compared to the control group (B), while there is a decrease in interleukin- 6 levels in the group (A) than in the group (B) without a statistical significance (P = 0.52). Conclusion: Aerobic training can be beneficial in increasing functional capacity.
Key words:
stem cell transplantation, graft vs host disease, aerobic exercise, interleukin-6, six-minute walk test
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