Tag: Jacek J. Klawe

Circadian changes of arterial blood pressure in obese subjects after-night-shift work

Jacek J. Klawe, Małgorzata Tafil-Klawe, Jan Talar, Wojciech Sikorski, Maciej Śmietanowski

Jacek J. Klawe, Małgorzata Tafil-Klawe, Jan Talar, Wojciech Sikorski, Maciej Śmietanowski – Circadian changes of arterial blood pressure in obese subjects after-night-shift work. Fizjoterapia Polska 2003; 3(2); 180-183

Abstract
Background. A number of papers have reported that blood pressure correlates positively with body weight in humans. The analysis of circadian variability of blood pressure in obese patients indicates an abnormal tone in regulatory mechanisms. The increased arterial blood pressure observed in healthy subjects after sleep deprivation suggests that in obese subjects there may be increased risk of arterial hypertension after night-shift work. Material and methods. The investigation was performed in 6 male obese subjects. 24-h blood pressure monitoring was performed in an isolation chamber where temperature and humidity were kept constant, after day- and night- shift work. Results. The values of mean arterial pressure during 24 h after night-shift work were significantly higher as compared with the values observed after daytime work (P < 0.001). Conclusions. 1. Obese subjects showed an intollerance of the night-work, manifesting by the increase in blond pressure of after night-work. 2. Night-work changes the circadian course of the blood pressure during 24 hours after night-work.

Key words:
shift work, arterial hypertension, obesity

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The neurogenic and metabolic regulation of blood flow in spinal nerves

Jacek Przybylski, Artur Stolarczyk, Łukasz Sawionek, Jacek J. Klawe, Małgorzata Łukowicz, Gunther Hildelbrandt

Jacek Przybylski, Artur Stolarczyk, Łukasz Sawionek, Jacek J. Klawe, Małgorzata Łukowicz, Gunther Hildelbrandt – The neurogenic and metabolic regulation of blood flow in spinal nerves. Fizjoterapia Polska 2004; 4(1); 1-7

Abstract

Background. The function of peripheral nerves depends upon an intact blood supply, but the mechanisms regulating blood flow through the blood vessels supplying peripheral nerves remain largely unclear. The aim of the present study was to examine the effect of stimulation of arterial and central chemoreceptors and unloading of arterial baroreceptors on sciatic nerve blood flow. In addition, we attempted to evaluate the role of hypoxemia and hypercapnia as local metabolic factors involved in the regulation of blood flow in the sciatic nerve of the rat. Material and methods. The study was carried out on 55 male Wistar rats with the body weight ranging from 300g to 350g. Sciatic nerve blood flow was measured, using a laser Doppler flowmeter, in anaesthetized rats at various arterial blood pressures and during hypercapnia and hypoxemia. Results. We found that sciatic nerve blood vessels do not exhibit autoregulation. Stimulation of arterial and central chemoreceptors did not result in any significant changes in sciatic nerve vascular resistance. During a decrease of mean arterial pressure, there was an increase in vascular resistance in sciatic nerve, which was abolished by pharmacological sympathectomy but not by alpha-adrenergic blockade. Conclusions. Our findings provide evidence that PaO2 and PaCO2 do not influence vasa nervosum resistance in the sciatic nerve.

Key words:
Sciatic Nerve, hypercapnia, hypoxemia, autoregulation, rat
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