Background. Spasticity in children with cerebral palsy (CP) leads to disturbances of balance between various muscle groups (e. g. extensors and flexors), often causing significant impairment of limb function even when there is only slight paresis. The primary task of motor exercises is to remedy motor disturbances to the extent possible, with particular attention to mastery of locomotion skills and increased manual dexterity. The purpose of our research was to evaluate the impact of tolperisone iontophoresis as an adjuvant therapy in the rehabilitation of children with CP. Material and methods. We examined 70 children with spastic CP, hospitalized in the „Górka” Children’s Comprehensive Rehabilitation Hospital in Busko Zdrój, Poland. The experimental group included 35 patients, as did the control group. Tolperisone iontophoresis was performed in the experimental group on the main muscle groups, using horizontal electrotherapy. Results. When the results achieved by the children in both groups were compared, we found statistically significant differences. Conclusions. The application of tolperisone iontophoresis causes improved manual and locomotor skills, as indirectly demonstrated by better test results for grip strength, manual dexterity, and Katz test results. Tolperisone iontophoresis should always be combined with motor rehabilitation.