Abstract

Background. Impaired wound healing is a disastrous medical problem associated with chronic diseases and aging. To accelerate skin regeneration many techniques have been researched laser and LED has been used for these purposes. Topical phenytoin is simple to use, safe, inexpensive and readily available drug and plays a significant role in the rate of healing of wounds. Objective. This study aimed to study the effects of irradiation with light emitting diode (LED) 670 nm in comparison to irradiation with LED 830nm for wound healing. Materials and Methods. three groups 24 mice per group received treatment as follows. Group I: Wounds followed up without any treatment modality. Group II: wounds irradiated with red LED 670 nm at fluence of 5 J/cm2. Group III: wounds treated by infrared LED 830 nm at fluence of 5 J/cm2. All treatments started from the 1st day postoperatively and up to three consecutive weeks or till complete healing of ulcer. Results. The results showed the fastest healing in the infrared group with more deposition of collagen fibers, larger amounts of granulation tissue, less edema. The second best treatment was the red LED 670 nm the non treated group as mice showed less evident features with less collagen fibers deposition. Conclusions. These data suggest that infrared LED 830nm combined is an effective enhancer of wound healing that stimulates the secretion of growth factors in the wound bed induce several modifications during the cutaneous healing process, especially in favoring newly formed collagen fibers to be better organized and compacted disposed. and led more deposition of collagen fibers.

Key words:

healing, bio modulation, LLLT