Zbigniew Kopański, Mariola Grabowska, Jan Tabak, Bożena Witkowska

Zbigniew Kopański, Mariola Grabowska, Jan Tabak, Bożena Witkowska – Effect of systemic cryotherapy on serum antioxidant status in patients with rheumatoid arthritis. Fizjoterapia Polska 2006; 6(4); 334-338

Abstract
Background. Determination of total serum antioxidant status (TSAS) in patients with rheumatoid arthritis (RA) and determination of the effect of systemic cryotherapy on the systemic serum antioxidant pool in these patients. Material and methods. The prospective study included 130 patients (35 men and 95 women) aged 31 to 68 years, receiving treatment for RA. All patients underwent systemic cryotherapy. TSAS was determined at baseline and after completion of the cryogenic therapy (within one hour after the end of the last of a series of 10 cryogenic procedures — C1 follow-up, and 14 days after the end of the treatment — C2 follow-up). Results. There was wide variation in TSAS in the study population at baseline, from values well below reference values to values within the reference range. The patients were accordingly divided into two arms: one including patients (13.8% of the total) with TSAS values within the reference range (GB1), and one comprising patients (86.2% of the total) with TSAS values below the lower reference limit (GB2). The cryogenic therapy did not effect statistically significant changes in average TSAS values in GB1, whereas a statistically significant increase in average TSAS was seen in GB2 at C1 (immediately following completion of 10 cryotherapy procedures). 14 days later the average pool of serum antioxidants still remained at a high level, comparable with the values determined at C1. Conclusions. The cryogenic therapy increased TSAS in the vast majority of the patients. Substantial changes was characteristically observed in the patients with baseline TSAS below the lower reference limit.

Słowa kluczowe:
systemic cryotherapy, serum antioxidants, rheumatoid arthritis

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