Background. Patients who are unconscious after traumatic brain injury, as well as those with para- and tetraplegia, are at high risk for the formation of decubitus ulcers. Even small ulcerations can cause the patient’s clinical status to deteriorate, and require proper conservative treatment and/or surgery. The present article presents methods for the surgical treatment of decubitus ulcers in patients with brainstem injuries. Material and methods. Twelve patients with brainstem injuries are presented, in whom pressure sores had developed, due to neglect in nursing care prior to their admission to our center. Preparatory procedures were initiated while the patient was still comatose; as soon as the danger had passed, surgical treatment was initiated. Various techniques were used, depending on the localization and extent of ulceration. In most cases (85%) musculo-cutaneous flaps were used to fill the defect after excision of the ulcers; this led to good blood supply to the hypoxic tissues, good cushioning of the places affected by pressure, and quick healing. Results. The techniques used here produced relatively quick healing (ca. 21 days) without complications in eleven cases. In one patient, admitted with multiple bedsores, treatment time was considerably prolonged due to complications (ca. 10 weeks). Conclusions. The cooperation of a multidisciplinary treatment team led to good preparation of patients for surgery. The techniques used here provided complete healing of all the decubitus ulcers treated. Specialists in rehabilitation and physiotherapy should be thoroughly familiar with the basic principles and possibilities of preventing decubitus ulcers, as well as the available methods of conservative and surgical treatment.