Abstract
Purpose of the study. To evaluate the efficacy of extremely low frequency pulsed electromagnetic field (ELF-PEMF) on renal function following paracetamol induced toxicity rat model by improving renal function test (serum urea and creatinine level).
Methods. 22 rats of 10 ± 2 months old received a single dose of paracetamol (PC) (2 g/kg) Paramol® (500 mg/tablet) and subdivided into two groups randomly. Group A (control group): received only PC dose and group B (PEMF group): were exposed to ELF-PEMF at four frequencies (1, 10, 20, and 40 Hz) in three series, the transition period of each pulse train is 4 min, followed by 1 min of rest, each series is performed for 20 min, for a total of 60 min/daily applications for 4 weeks. Assessment was done by measuring renal function test (serum urea and creatinine level), first after the induction of PC toxicity, then after 4 weeks at the end of the experiment.
Results. This trial revealed a significant improvement in renal function in the PEMF group after the exposure to ELF-PEMF by showing a significant decline in both creatinine level (p = 0.001) and serum urea (p = 0.003). A significant reduction in both creatinine and serum urea at post treatment in compare to pre-treatment (P-value = 0.0001)
Conclusion. By evaluating the efficacy of ELF-PEMF in kidney toxicity rat model inducted by a toxic dose of paracetamol, we observed an obvious improvement in kidney function in the PEMF group.

Keywords
Pulsed electromagnetic field, renal function, paracetamol