Effect of aerobic exercise on functional capacity and interleukin-6 level post allogeneic hematopoietic stem cell transplantation: A randomized controlled trial

Mohamed Rafat Borham, Azza Abdelaziz Abdelhady, Gamaleldin Mohamed Fathy, Emad Mohamed Ibrahim

Mohamed Rafat Borham, Azza Abdelaziz Abdelhady, Gamaleldin Mohamed Fathy, Emad Mohamed Ibrahim – Effect of aerobic exercise on functional capacity and interleukin-6 level post allogeneic hematopoietic stem cell transplantation: A randomized controlled trial. Fizjoterapia Polska 2022; 22(1); 100-107

Abstract
Background. Transplantation of hemopoietic stem cells has been extensively used as a curative modality to treat blood malignancies and cases of bone marrow failure. Objective. To examine the effect of aerobic exercises on functional capacity and interleukin-6 levels on patients post allogeneic hematopoietic stem cell transplantation (HSCT). Design. A quasi-experimental, randomized, single-blind design. Setting. Nasser Institute’s out-patient clinic for bone marrow transplant and Belqas central hospital. Methods. Forty women having chronic Graft versus Host Disease post hemopoietic stem cell allotransplant, with an age range of 20 to 30 years and body mass index between 18.5 and 24.9 kg/m2, were randomly designated into two equal groups (n = 20) (A and B). The study group (A) participated in a supervised aerobic exercise program of moderate intensity, with a score of 12-14 on the Borg scale for ‎perceived exertion, together with a specific medication routine, whereas the control group (B) was only given their medication routine. The exercise program consisted of 40 minutes on the stationary bicycle, with a warm-up and a cool-down period of 5 minutes each and 30 minutes as an active phase, 3 times per week for 3 months Both functional capacity, measured by a 6-minute walk test (6 MWT), and interleukin-6 blood level were assessed before starting the aerobic training and medical routine and after 3 months of the intervention. Results. The analysis showed a significant increase (P < .001) in the distance walked and assessed by 6 MWT in the group (A) compared to the control group (B), while there is a decrease in interleukin- 6 levels in the group (A) than in the group (B) without a statistical significance (P = 0.52). Conclusion: Aerobic training can be beneficial in increasing functional capacity.
Key words:
stem cell transplantation, graft vs host disease, aerobic exercise, interleukin-6, six-minute walk test
Pobierz/Download/下載/Cкачиваете   免費下載(僅限英文版)

The effect of qualification method on effect of physiotherapy of COPD patients

Katarzyna Bogacz, Marek Woszczak, Jan Szczegielniak

K. Bogacz, M. Woszczak, J. Szczegielniak – The effect of qualification method on effect of physiotherapy of COPD patients. FP 2017; 17(2); 112-120

DOI: https://doi.org/10.56984/8ZG0D9304

Abstract

Objective. The study was aimed at the assessment of qualification of COPD patients participating in the pulmonary rehabilitation program covering models A, B, C, D and E.
Materials and methods. 174 COPD patients treated  were included in the study. Exercise tolerance was assessed in all patients, based on a treadmill test or 6-minute walk test. The physiotherapy program was based on efficiency trainings of intensity determined individually for each patient. A result of the exercise test constituted a basis for qualification for an appropriate rehabilitation model and for individual selection of intensity level. The exercise test was repeated three weeks later, after the end of the physiotherapy program.
Results. Results of pre- and post-rehabilitation tests in both groups were statistically analysed. Intra-group assessments used t-Student test for dependent samples. Mean values of individual indexes, standard deviations and mean growth of all indexes were calculated. A chart frame area plot of all variables was used for the analysis of test results.
Conclusions. 1. A significant improvement of exercise tolerance was observed after a physiotherapy program both in patients assessed using the modified Brice’s protocol and in those assessed using the 6-minute walk test
2. The study demonstrated that the assessment of exercise tolerance is a basis for selection of exercise intensity level.
3. Efficacy of physiotherapy of COPD patients participating in pulmonary rehabilitation programs was demonstrated.

Key words:
Chronic obstructive pulmonary disease, modified Bruce’s protocol test, 6-minute walk test, qualification for physiotherapy, effects of physiotherapy

Pobierz/Download/下載/Cкачиваете 免費下載(僅限英文版)